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Spravato
Nasal Spray

It’s a completely new way of treating depression.

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It’s a completely new way of treating depression. Spravato appears to be effective in cases where other standard antidepressants have failed. Antidepressants like sertraline (Zoloft), bupropion (Wellbutrin) and duloxetine (Cymbalta).

How does it work ?

It acts very rapidly. “We used to tell our patients it could take weeks or even a few months before they would begin feeling better, and now this offers potential benefits within hours or days,” he explains.

“Almost all of the other antidepressants on the market target two main neurotransmitters: serotonin and norepinephrine,” Sanacora says. These two neurotransmitters, in turn, activate another neurotransmitter, glutamate, which is what boosts your mood. Esketamine instead works directly on glutamate, which is why its effect is almost immediate.

SPRAVATO™ is an FDA approved prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

SPRAVATO must be administered under the direct supervision of a healthcare provider. A treatment session consists of nasal administration of SPRAVATO and post-administration observation under supervision.

“It’s quite possibly the biggest advance for mental health in the past 50 years,” says Gerard Sanacora, M.D., director of the Yale Depression Research Program in New Haven, Conn. “It truly offers hope to people who have not responded to classical standard antidepressant treatments.”

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